Human TOPBP1, C-His Tag Protein
cat.: HA210666
| Product name: | Human TOPBP1, C-His Tag |
|---|---|
| Catalog No.: | HA210666 |
| Bio-Activity: | Testing in progress. |
| Purity: | >95% as determined by SDS-PAGE. |
| Endotoxin: | Less than 1.0 EU per μg by the LAL method. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
| Background: | Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR. |
| Source: | E.coli |
| Storage: | Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Reconstitution: | Reconstitute at 250 μg/ml in sterile water. |
Images
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Fig1: Protein on SDS-PAGE under reducing (R) condition. |
Note: All products are “FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE”.