Human LTA, Tag Free Protein
cat.: HA210742
| Product name: | Human LTA, Tag Free |
|---|---|
| Catalog No.: | HA210742 |
| Bio-Activity: | Testing in progress. |
| Purity: | >95% as determined by SDS-PAGE. |
| Endotoxin: | Less than 1.0 EU per μg by the LAL method. |
| Formulation: | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol. |
| Background: | Lymphotoxin-alpha (LT-alpha ), also known as Tumor Necrosis Factor-beta (TNF-beta ), is a member of the TNF Superfamily. Human LT-alpha /TNF-beta is a 22 kDa protein that shares 73% amino acid sequence identity with mouse and rat LT-alpha /TNF-beta. Secreted LT-alpha forms homotrimers that bind and activate TNF RI/TNFRSF1A, TNF RII/TNFRSF1B, and HVEM/TNFRSF14. LT-alpha /TNF-beta also forms heterotrimers with plasma membrane-localized LT-beta to bind and activate the LT-beta R/TNFRSF3. In addition to its cytotoxic action on tumor cells, LT-alpha /TNF-beta mediates lymph node development, inflammation, and immune function. LT-alpha /TNF-beta is expressed in activated T- and B lymphocytes and contributes to autoimmune disease. |
| Source: | HEK293 |
| Storage: | Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃ It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Reconstitution: | Reconstitute at 250 μg/ml in sterile water. |
Images
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Fig1: Protein on SDS-PAGE under reducing (R) condition. |
Note: All products are “FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE”.